Macrophage Inflammatory Protein-1alpha 조혈간세포 억제 작용에 관한 실험적 연구
In vitro stem cell suppression of macrophage inflammatory protein-1alpha
서기항, 고승오, 조기현, 이정우,
소속 상세정보
서기항 ( ) - 전북대학교
고승오 ( ) - 전북대학교
조기현 ( ) - 전북대학교
이정우 ( ) - 전북대학교
KMID : 0360119960180020286
Abstract
The proliferation of bone marrow stem cell compartment is thought to be under both positive and negative controls by cytokines and colony stimulating factors. Macrophage inflammatory protein-1α(MIP-1α) has been assessed for its potential to
protect
hematopoietic stem cells from cytotoxic effects of a cycle-specific antineoplastic agents. We have tested the ability of MIP-1α to suppress the proliferation of stem cell line Du.528.101 in variety of active status by using [3H]-thymidine
incorporation
test.
@ES The results were as follows.
@EN 1. The effect of MIP-1α on steady-state Du.528.101 cells represented the cell growth suppression at the concentration of 10, 50, 100nM of MIP-1α(P<0.01).
2. MIP-1α stimulated the proliferation of Du.528.101. cells previously treated with IL-1 at the concentration of 5, 50nM of MIP-1α(P<0.01).
3. The suppression effect of MIP-1 on Du.528.101 cells at the concentration of 5, 50nM was shown when cells were treated with MIP-1α before activating with IL-1β(P<0.01).
4. The growth rate of synchronized cells were slower than that of non-synchronized ones, and MIP-α represented the similar suppression effect on both synchronized and non-synchronized and non-synchronized cells.
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